The CIR Procedures established an Expert Panel to set priorities and
review and assess ingredient safety data. The seven CIR Expert Panel
voting members include physicians and scientists who have been publicly
nominated by consumer, scientific and medical groups, government
agencies and industry. Three liaison members serve as non-voting members
representing the U.S. Food & Drug Administration (FDA), Consumer
Federation of America and Cosmetic, Toiletry & Fragrance Association
(CTFA). By uniting industry, consumers and government, the Expert Panel
creates a unique environment for discussions affecting public
safety.
Working on the high priority ingredients, CIR staff conduct extensive
literature searches, compile data and prepare draft reports. CIR staff
organize the literature into chemistry, including physical properties
and manufacture; use, including cosmetic and non-cosmetic; general
biology, including absorption, distribution, and metabolism; animal
toxicology, including acute, short-term, subchronic, and chronic
studies, as well as dermal irritation and sensitization; and a clinical
assessment, which may include epidemiology studies along with classic
repeat insult patch tests. In vitro test data are also gathered and
incorporated into the review.
If the open, scientific literature contains insufficient information,
the Panel will call on industry or other interested parties to undertake
specific studies or to provide previously unpublished data. After
completion of a development process that includes multiple opportunities
for public comment and open, public discussion of the report, a Final
Report is issued. These final reports are available from CIR.
Eventually, CIR final reports are published in the International
Journal of Toxicology. |
